YES YES YES!!!!
Our *new design does not touch the iPhone screen at all so thus, any screen protector on the actual screen will not effect anything.
Due to the tight fit, any screen protectors (even those that are extremely thin) on the sides or back of the phone will not work.
*Screen protectors of any kind should not be used with the older model of iPhone 4/4s case sold on our site previous to May 2013.